Dynamic and Interactive Microscopy
Luminos' bidirectional microscopy platform enables dynamic and interactive microscopy. Multi-wavelength patterned illumination allows targeted optogenetics, photochemistry, and structured illumination microscopy. High-speed and high-sensitivity fluorescence microscopy probes sample dynamics with millisecond time-resolution over a large field of view. Together, these tools open a two-way conversation between the researcher and the sample.
High-Speed Imaging
The Luminos imaging platform offers the highest combination of sensitivity, speed, and field of view of any microscope. These capabilities enable simultaneous voltage imaging from thousands of neurons, cardiomyocytes, or other excitable cells.
Dynamically Patterned Illumination
Luminos microscopes have >4M individually controlled optical stimulus points, each updated at > 10 kHz. Simultaneous patterning of multiple wavelengths allows targeted photochemistry, optogenetics, or structured illumination microscopy.
Optically Responsive Life
Luminos provides a full suite of optogenetically engineered life forms, including transgenic mice, engineered hiPSCs, and stable cell lines; as well as viral vectors, plasmids, and chemical reagents.
Intuitive and Powerful Software
The Luminos instrument control software synchronizes all aspects of the experiment and enables adaptive experimental designs where the stimuli automatically respond to the sample features.
Example applications
Biological Signaling Analysis
Luminos tools facilitate sub-cellular to tissue-scale mapping of biological signaling cascades. These measures are useful in studying nervous system function, embryonic development, cancer, and wound healing.
Genotype-Phenotype Relations
Luminos' proprietary targeted photochemical labeling products enable optical pooled screens for protein engineering and the determination of genotype-phenotype relations. These capabilities have applications ranging from basic research to drug discovery and development.
Our Impact
15
Years of Innovation
50+
Publications
100+
Labs using Optopatch technologies